Dr. Jim Schoster
For quite some time I have been wanting to try using a topical CAI to try to shrink anterior chamber uveal cysts that are very large and affecting vision where owners elect no surgery. My hypothesis is that the lining of the cyst is the same as the secretory epithelium at the tips of the non-pigmented ciliary epithelium on ciliary processes responsible for making aqueous humor.
So I finally came across a patient with those criteria and a motivated and diligent owner.
In November of last year (first picture) I started topical dorzolamide at TID.
In January of this year I could see a change in that the cyst was smaller and a little wrinkled (second picture).
Then last week ( the cyst was collapsed and flat and had multifocal areas of translucency) ( third picture). I stopped the dorzolamide and will recheck in two months to see if the cyst inflates again or not.
I figured that the cyst was adherent to the endothelium from when I first saw the patient due to the cyst size and pressing against the endothelium for a while. SO as the cyst shrank, the wall remained attached to the endothelium.
Perhaps as the dog ages the endothelium may decompensate or may be not.
I will post again in two months.